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It works by enhancing the activity of neurotransmitters called noradrenaline and serotonin in the brain.

J Clin Psychiatry 1996;57 Suppl -25 "Mirtazapine (Org 3770) is a new antidepressant with prominent alpha 2-adrenergic auto- and heteroreceptor antagonistic properties and no effect on monoamine reuptake.

Mirtazapine increases noradrenergic and serotonergic transmission, as measured by on-line microdialysis and by enhancement of noradrenergic locus ceruleus and serotonergic raphe nucleus cell firing.

Neurotransmitters act as chemical messengers between nerve cells.

When noradrenaline and serotonin are released from nerve cells in the brain they act to lighten mood.